and its impact on hematological components in end stage renal failure patients in a tertiary care hospital in India

Chronic kidney disease is a global health burden with a high economic cost to health system and is an independent risk factor for cardiovascular disease. The final stage of chronic kidney disease is End-stage renal disease in which the kidneys no longer function well enough to meet the needs of daily life. Dialysis is a treatment that replaces many of the kidney's important functions. Hematological profiles are the main target in renal disease and this becomes more pronounced as the disease progresses. The study was conducted in a tertiary care hospital in Southern part of India taking a sample size of about 221 ESRD patients who are on dialysis with the main objective of evaluating the impact of hemodialysis on essential blood components after dialysis. The study revealed that there was a marked decrease in Hemoglobin concentration and platelet counts in 89.1% and 97% of patients respectively. The leukocyte count increased in 81.5% of patients, decreased in 13.6% of patients and remained stable in 4.9% of patients. This study concluded that there is a noticeable effect of hemodialysis on hemoglobin concentration (Hb), red cell count, leukocytes and platelet count. Hence extreme care must be taken in screening and directing the therapy to ESRD patients on dialysis to prevent serious complications.