The efficacy of intranasal administration of Dexmedetomidine, Ketamine and morphine combination to young dogs

The sedative effects of intranasal dexmedetomidine, ketamine and morphine combination were evaluated in young dogs. A combination of 0.1 mg/kg dexmedetomidine, ketamine 20 mg/kg and 0.4 mg/kg morphine was administered by inserting a lubricated catheter in intranasal. The sedation score was classified as ‘moderate’ from 2 to 10 minutes, ‘light’ from 10 to 30 minutes, the sedation level was insufficient from 30 to 45 minutes. The dogs were all awake at 45 minutes. Heart rate and rectal temparature did not change significantly from baseline at any time. Respiratory frequency decreased significantly (P<0.05) from baseline. Also SpO2 progressively dropped 10- 15 minutes when O2 supplementation was started, increasing significantly. PaCO2 enhanced significantly (P<0.05) at 10, mins and PaO2 lessening significantly (P<0.05) at 10, mins compared with baseline value. The intranasal dexmedetomidine-ketamine–morphine combinations has been successfully used for modarate sedation for 10 minutes in young dogs.