Role of inflammation to malnutrition events in predialysis chronic kidney disease patients

Background: Malnutrition is often found in patients with chronic kidney disease (CKD) and inflammation is an important factor in the complications of CKD. However, until now it is unclear whether the inflammatory reaction is a major cause of malnutrition or just merely signs in CKDpatients. Aim: Know the role of inflammation to the incidence of malnutrition in predialysis CKDpatients. Methods: Observational study with cross sectional method on October 2010-March 2011 in Wahidin Sudirohusodo Makassar. The study population was CKD patients men and women (15-70 years) who had never received renal replacement therapy and met the inclusion criteria. Results: This study involved 64 predialysis CKD subjects (29 men (45.3%)), in which 54 subjects (84.4%) with malnutrition. The correlation between inflammation and glomerular filtration rate (GFR) shows GFR is negatively correlated with hsCRP levels (p=0.762) on malnutrition subject, but shows positive correlation in not malnourished subjects (p=0.250). In GFR <15 mL/min/1,73m2 there is a positive correlation between albumin and SGA score with levels of hsCRP levels (p=0.085; p=0.488); BMI and LLA are negatively correlated with hsCRP levels (p=0.426; p=0.345). In GFR 15-29 mL/min/1,73m2 there is a negative correlation between albumin, BMI and LLA with hsCRP levels (p=0.699; p=0.046; p=0.936); SGA scores is positively correlated with hsCRP levels (p=0.581). In GFR 30-59 mL/min/1,73m2 there is a negative correlation between albumin levels and LLA with hsCRP levels (p=0.071; p=0.027); SGA score and BMI is positively correlated with hsCRP levels (p=1.000; p=0.350). In GFR ≥60 mL/min/1,73m2 there is a positive correlation between albumin, SGA score, BMI and LLA with high levels of hsCRP (p=0.800; p=0.400; p=0.000; p=0.262). Conclusion: We found an increased incidence of malnutrition and inflammation in predialisis CKDsubjects, but no correlation between them.