Status of Vitamin C, Vitamin E and glutathione in diabetic patients with and without Dyslipidemia

Hyperglycemia in DM is associated with increased lipid peroxidation and excessive production of free radicals which lead to oxidative stress by autoxidation of glucose. It is an important pathogenic mechanism in the development of diabetes and its complications. The research work included 50 healthy controls and 100 patients with type 2 diabetes mellitus. Fasting blood samples collected using aseptic technique were evaluated for serum levels of the fasting blood glucose, triglycerides, total cholesterol, HDL, LDL, vitamin C, vitamin E and glutathione by spectrophotometric method. On the basis of lipid profile the patients were categorized into 2 groups diabetic with dyslipidemia and diabetic without dyslipidemia. It was observed that vitamin C, vitamin E and glutathione levels in serum are significantly depleted in diabetics with dyslipidemia as compared to diabetics without dyslipidemia and control.