Role of fibroscan to detect fibrosis of liver in the patients of nonalcoholic fatty liver disease in comparison with ultrasonography

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disorders in the world. The global burden of NAFLD is estimated to be as high as one billion. NAFLD is the presence of fat accumulation in hepatocytes when other secondary causes like heavy alcohol consumption is not present. The standard diagnostic test of fatty liver disease is liver biopsy. Liver biopsy is an invasive procedure. A potentially non-invasive method used as an alternative to liver biopsy for diagnosis of fibrosis and hepatic steatosis is the measurement of liver stiffness using transient elastography. Material and methods: It was a prospective study of 72 patients visiting Gastro and Medicine OPD of RNT medical college Udaipur. Suspected patients of fatty liver disease screened with ultrasonography. Those with fatty liver disease taken into study and screened for fibrosis using non-invasive methods Fibro scan, CBC, LFT, TSH level, B12 level, HbA1c level and compared with ultrasonography grading of fatty liver. Results: In this study, out of 72 patients 47 patients had grade 1, 17 had grade 2 and 8 had grade 3 fatty liver. Maximum number of patients were in age group 41-60. Male patients predominates than females. In this study more BMI patients had high fibrosis grading by ultrasonography or fibro scan both. With progression of fibrosis there was elevation of SGOT, SGPT levels. In this study we observed that with advancing fibrosis there is high RBS and HbA1c level. Also observed that with high fibrosis value there is reduction in platelets count. Conclusion: Male has higher prevalence of NAFLD in the age group 41-60. Significant relation observed with RBS, HbA1c, SGOT, SGPT, HDL, LDL, TG, PT/INR, and prevalence of fatty liver by USG and Fibro scan. Also observed that Fibro scan helps in diagnosing advanced fibrosis and cirrhosis prior to ultrasonography.