The effect of cigarette smoking and smoking cessation on fibrinogen level in Sudan

Cigarette smoking is one of the major health hazards, and it contributes significantly to cardiovascular morbidity and mortality. The aim of this study was to determine the effect of smoking and smoking cessation on fibrinogen level among Sudanese population. 150 adult men aged 19-54 years old were enrolled (50 cigarette smokers, 50 Ex-smokers and 50 non-smokers). Citrated blood samples were collected, plasma were separated and stored at -80 °C, and fibrinogen levels were measured by Clauss method. Fibrinogen levels were significantly higher among smokers group compared to non- smokers group (P<0.000) and smoking cessation group (p 0.000). Increase fibrinogen levels were significantly associated with the duration of cigarettes smoking (p value 0.000), and the number of cigarette smoked per day (p value 0.000). In conclusion, smoking potentially increases fibrinogen level. Our results suggest that the effect of smoking on fibrinogen level is reversible with smoking cessation. Increased fibrinogen level in the smokers is dose-dependent, that is directly associated with the smoking duration and frequency.