The this research aims to determine the way in which variations in the exchange rate affect the operations and financial results of the companies micro and small enterprises located in the urban area of the border city of Mexicali, Baja California, to making acquisitions abroad. Design research is descriptive, experimental, and transverse. Using as an instrument of measuring a questionnaire that is applied to 80 companies that perform operations on currency foreign. Within the results showed that companies have had to raise their prices constantly, causing a decrease in sales and profitability. Besides size and financial structure of such enterprises is not equipped with any type of coverage to protect against this type of economic events, situation that affects its liquidity and threatening is permanent. Some companies have established some strategies to remain in the market because they are not only affected by the volatility of the exchange rate but also by the increase of tariffs on import products and are essential to its operation.