Myasthenia Gravis when caused by a tumor in the thymus, is potentially curable. We present a case report of a young girl who was diagnosed to have Myasthenia Gravis due to thymictumor which was removed thoracoscopically. She had a stormy post-operative period with repeated intubation and ventilatory support caused by circulating antibodies for which she required plasmapheresis. She made a complete recovery. In this article, we highlight the technical aspects of thoracoscopy and the need for post-operative plasmapheresis to tackle the circulating antibodies.