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Synthesis, characterization and assessment of biological activities of inorganic derivatives of Dihydroquinoline 3 carboxylic acid

Author: 
Gul Muhammad, Asia Naz, Fouzia Haider, Almas Kanwal, Faria Khurshid and Muhammad Ishaq, M.R.
Subject Area: 
Life Sciences
Abstract: 

To develop new drugs that inhibit growth of pathogenic microorganisms, metal derivatives of dihydroquinolone 3 carboxylic acid are assessed. Metal complexes with the fourth-generation fluoroquinolone antibacterial agent moxifloxacin (MOXI) or 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid have been synthesized and characterized with physicochemical and spectroscopic techniques such as TLC, FTIR, 1H- NMR, UV-Vis spectroscopy and Mass spectroscopy and assessed for antioxidant and antibacterial effects. Both 1H NMR and FTIR spectra clearly showed that Moxi-metal complexes are formed due to change in their carboxyl stretching band in IR, H-2 and H-5 peak position in 1H NMR. All the Moxi-metal complexes showed significant antibacterial and antioxidant effects. Among all metal complexes tested Moxi-Mo showed remarkable antibacterial effect and Moxi-Cd complexes showed good antibacterial activity. The Moxi-Cd complex showed antioxidant effects almost similar to that of standard agent (IC50 = 8.26 µg/ml),Moxi-Mo (IC50 = 3.01 µg/ml) and Moxi-Mg(IC50 = 3.62 µg/ml) metal complexes showed higher antioxidant activity than the parent drug.

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