The goal of deep vein thrombosis prophylaxis is prevention of mortality and multiple other major or minor complications resulting from venous thromboembolic events. Many guidelines have been proposed and available for ready reference and are also rigidly followed in patients undergoing knee arthroplasties. The medicolegal ramifications of obviating the deep vein thrombosis prophylaxis is immense. We take a review of all the available medications and treatments modalities including mechanical devices in the present article.