A study of some biochemical and histopathological changes in male laboratory rats treated by Pesticide abamectin

Abamectin is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated administration of Abamectin (Vapcomic- 1.8% EC) injection formulation on albino male rats the various biochemical parameters and histopathological changes were noted. Two groups each of five of albino male rats were utilized in the current investigation. Abamectin was administered interaperitoneal which treated with (0.1 mg\kg, 0.6 mg\kg) body weight daily for 15 days. At the end of the study period blood samples were collected from all the groups to measure plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST activities, and the levels of total protein and cholesterol level changes in biochemical parameters were more intense in male rats from group T2 than those reported in group T1. The levels of ALT AST were significantly elevated in rats from group T2 when compared to the control group. In group T1 and T2 showed a significant decrease in the levels of total protein and cholesterol.