Background: A seizure (from the latin word “to take possession of”) is a paroxysmal event due to abnormal, excessive, hypersynchronous discharge from an aggregate of central nervous system neurons. Aims and Objectives: To Study Clinical profile of Seizure disorders at Tertiary health care center. Methodology: This was a cross-sectional study in 1680 patients of seizure disorder in the age group 18 and above years at tertiary health care center of GMC Jammu, General Medicine department during the two years from 2016 to 2018. Result: Out of the 1680 patients, 63.1% were males and 36.9% were females .86.2% (1448 patients) of the study patients ,had generalized tonic clonic seizures, 3.9% (65 patients) had partial seizure with secondary generalization, 4.8% (80 patients) had complex partial seizures and 5.2% (87 patients) had simple partial seizures. 25.5% (428 patients) of the cases, no cause could be found in spite of rigorous investigation and they were termed ‘idiopathic’ or ‘cryptogenic’. 12.3% (206 patients) of the cases were due to space occupying lesions. 7.5% (126 patients) had electrolyte imbalance, 18.8% (316 patients) had metabolic derangements. Cerebrovascular accidents constitute the most common cause as 30.4 % of patients. Conclusion: It can be concluded from our study that most common type was generalized tonic clonic seizures (GT CS) and most common etiology was stroke followed by idiopathic, metabolic, Space occupying lesion, electrolyte imbalance, metabolic derangements and infections.