Serum Apolipoprotein B-100 In Type 2 Diabetes Mellitus

OBJECTIVES: To evaluate the levels of serum apolipoprotein B-100 in type 2 diabetes mellitus with and without complications. MATERIALS AND METHODS: The study was conducted on 96 Type 2 Diabetes Mellitus patients (thirty three with cardiovascular complications and another sixty three without cardiovascular complications) attending Diabetic Clinic and Medicine Ward RIMS, Imphal. Serum Apo-B was estimated by ELISA and enzymatic methods were used for estimation of serum lipid parameters (Triglycerides, Total Cholesterol and HDL cholesterol were measured). Fasting and postprandial blood sugar were measured by glucose oxidase method. RESULTS: Serum apolipoprotein-B levels for Type 2 Diabetes Mellitus patients with and without complications were found to be 2 (0.1 – 6.5) g/l and 1.1 (0.2 – 7.4)g/l respectively. Both of these were significantly higher (P < 0.05) than normal value (0.85 g/l – 1.0 g/l) and patients with cardiovascular complications had higher serum apo-B levels than those without complications (p < 0.05). Serum apo-B was positively correlated with total cholesterol (r = 0.339, P < 0.05), Triglycerides (r = 0.373, P < 0.05), VLDL (r = 0.367, P < 0.05) and LDL-cholesterol level (r = 0.356, P < 0.05) and was negatively correlated with HDL-cholesterol level (r = - 0.393, P < 0.05). CONCLUSION: Raised serum apolipoprotein B-100 level may have some relationship with vascular complications in Type 2 Diabetes Mellitus especially coronary heart disease. Serum apolipoprotein B-100 may be a preferred marker of coronary heart disease in Type 2 Diabetes Mellitus patients.