The growing field of Stem cells therapy has been proving its accurate results day by day due to the continuous researches. It is also found to be beneficial to various non-curable diseases that had no specific treatment earlier. These cells are the principal cells due to its unique and special property of capability to differentiate too many other cell types, its potency and its self-renewal. The stem cell therapy has been recently tried on the Orofacial region for the regeneration of various Soft and Hard tissues namely Enamel, Dentin, Pulp and Alveolar bone using the adult mesenchymal stem cells. Very few researches are conducted on the stem cell therapy for oral premalignant and malignant lesions like oral ulcers, leukoplakia, oral submucous fibrosis, lichen planus, oral cancer and others. Moreover, there is very less literature available on the functionality and efficacy of stem cell therapy application for these lesions and so the present review will enlighten about the functionality, efficacy and accurateness of the stem cell therapy for oral premalignant and malignant lesions. All the articles for the review were taken from the esteemed data bases like PubMed, Cochrane, EBSCO and more.