The role of developing breast cancer in alteration of estrogen level in sudanese women

This study was carried to determine the concentration of serum estrogen in women with breast cancer using enzyme linked immunosorbent assay. Among 150 breast cancer female patients and 80 healthy females (control), venous blood samples were collected sera were separated to be used in estrogen measurements. The results showed that developing breast cancer decreased the estrogen level significantly less than the control. The age grouping showed significant effects on estrogen levels, in which women below 20 years and those above 50years showed the least levels while women in 30-39 years showed the highest levels. The estrogen level in women with breast cancer was decreased by increasing the number of pregnancy showing the minimum level in those with pregnancy of more than 5 times and the maxim level in those who were not get pregnant. Some other disorders associated with breast cancer made significant changes in estrogen level. The diabetes mellitus lowering the level significantly, hypertension increasing the level significantly, but those with no history showed highest level (significantly).