Carrier technology provides an interesting as well as an intelligent approach for the delivery of the drug. Some general methods of delivery of the drug are by coupling the drug to a carrier particle such as microsphere, nanoparticles, liposome’s, etc. Microsphere constitutes an important part of this particulate drug delivery system because of their small size and other efficient properties. Among all these drug delivery system mucoadhesive microsphere are new technology as it provide better drug absorption as they get adhere to the mucosal surface and release are drug for prolonged time the article reviewed about the new technologies and methods for preparation of mucoadhesive microsphere in brief.