There is a dynamic balance between demineralization and remineralization in the oral cavity that determines the occurrence of dental caries. If the demineralization phase continues for a long period of time, there is mineral loss beneath a relatively intact enamel surface leading to the initial carious lesions known as “white spot lesions” Remineralization of such early carious lesions may be possible with a variety of remineralizing agents, fluoride being the cornerstone in caries prevention. The goal is to manage non cavitated lesions non invasively through remineralization in an attempt to prevent disease progression and improve aesthetics, strength, and function. Hence, the purpose of this review is to have an in-depth knowledge of the various remineralizing agents aiming to treat early carious lesions.