Water is the most precious natural source on our planet, solid waste disposal will increase the contamination in drinking water sources. Hyderabad, the second largest city of Sindh province is situated on the left bank of Indus River. It was observed that the large volume of refuse is left and burned in the premises of the main drinking water sources of Hyderabad and this raw water is supplied to consumers, causing water borne disease outbreaks. Water samples were collected from inlet and out let filter plants of study area, at locations Hyderabad. pH, Conductivity, Salinity, TDS (Total Dissolved Solids)and Turbidity were analyzed on the spot. While other quality parameter such as Arsenic, Chlorides, Fecal coliforms, Total Coliforms and E.coli were also analyzed using standard methods. The bacteriological result shows that the all samples contain unacceptable number of coliforms bacteria. The microbiological contaminants and other causative agents are major problem of the community the government must have to take necessary steps for Safe drinking water.