Protective effect of mosinone-a on biomembrane integrity in 7, 12 dimethyl benz [a] anthracene (dmba) induced hamster buccal pouch carcinogenesis

The present investigation the protective effect of Mosinone-A on cellular integrity by measuring the status of lipid profile, osmotic fragility and membrane bound enzyme activity in 7, 12-Dimethylbenz (a) antharacene (DMBA) induced oral carcinogenesis. A total number of 24 golden Syrian hamsters were randomized into 4 groups of 6 animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2 mg kg-1 b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Group IV animals were received Mosinone-A alone throughout the experimental period. We observed altered levels of lipids and membrane bound enzyme activity in DMBA painted hamster. Oral administration of Mosinone-A 2mg/kg b.wt significantly prevented the tumor formation as well as normalized the above said biochemical variables in DMBA painted hamster. Mosinone-A has potent efficacy to exert their anticarcinogenic effect by modulating the status of lipid, integrity of cell membrane in DMBA induced hamster buccal pouch carcinogenesis