PROTECTIVE EFFECT OF MORIN AGAINST ETHANOL INDUCED RENAL DAMAGE IN MALE ALBINO RATS

Morin, a bioflavonoid with antioxidant property, is a constituent of many herbs and fruits that are used as herbal medicines. It exhibits many biological activities and possibly even has protective effects against chronic renal diseases. The present study aims to study the protective effect of morin against ethanol-induced biochemical changes in kidney. Male albino rats were divided into four groups as follow; (1): control group, (2): control rats treated with morin (3) ethanol fed rats (4) ethanol fed rats treated with morin. Administration of ethanol (6g/kg BW) daily for a period of 60 days causes significant elevation in the levels of nephrotic markers such as urea, uric acid, creatinine and also significant elevation of kidney lipids such as total cholesterol, triglyceride, free fatty acid, and phospholipids. Ethanol also causes the significant decreased in the activities of membrane bound ATPases. However, ethanol fed rats treated with morin (60 mg/ kg BW, post orally once daily for a period of 30 days) significantly reduced the level of nephrotic markers, the lipids levels and increased the activities of membrane bound enzyme. The results of the present study strongly indicate that morin has potent reno-protective effect against ethanol induced oxidative tissues damage in experimental animals.