Prospective Randomized Study On Effect Of Tranexamic Acid On Wound Drainage Following Modified Radical Mastectomy For Cancer Breast

A prospective randomized study has shown that, in 50 women with breast cancer undergoing modified radical mastectomy with level III axillary clearance, perioperative and postoperative administration of tranexamic acid 1 g three times daily resulted in a significant reduction in the mean postoperative drainage volume compared with patient not receiving tranexamic acid (781.4248.64 vs. 1023196.3ml; p<0.001). The frequency of post drain seroma formation was increased by tranexamic acid administration (44% vs. 20%). None of the patient developed hematoma, flap necrosis in both the groups. Three patients developed wound infection in the study group and none in the control group. Two patients developed wound dehiscence in study group while 1 in the control group. Stage of breast carcinoma, total number of nodes dissected and number of lymph nodes positive for metastatic diseases does not effect the seroma formation. Tranexamic acid may be used for longer duration to reduce the frequency of postoperative wound complications following surgery for breast cancer.