Profilin is an actin-binding protein and engages in the dynamic turnover and restructuring of the actin cytoskeleton. The present study investigated the role of profilin in α7 ACh receptor trafficking. The selective PKCε activator DCP-LA increased cell surface localization of α7 ACh receptor in differentiated PC-12 cells, which was inhibited by knocking down PKCε. The effect of DCP-LA was also cancelled by knocking down profilin. In the cell-free kinase assay, profilin significantly enhanced the activity of PKCε activated by DCP-LA, although no PKCε activation was induced by profilin alone. It is indicated from these results that profilin stimulates translocation of α7 ACh receptor towards the cell surface by enhancing the activated PKCε activity.
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