Background: The Metabolic Syndrome is now considered as important factor of cardiovascular mortality around the world. Objective: This cross-sectional study aimed to determine the prevalence of metabolic syndrome in 81 voluntary men belonging to Toupouri ethnic group of Yaoundé Cameroon. The definition used is that of National Cholesterol Education Programm Adult Treatment Panel III (NCEP ATP III) 2001. Result: The prevalence of metabolic syndrome among Toupouri men was 29.62%. The prevalence of metabolic syndrome individual components was hypocholesterolemia HDL (64.20%), hypertension (60.49%), hypertriglyceridemia (37.03%), high waist circumference (22.22%) and hyperglycemia (2.46%). In our results 25.92% had three altered metabolic syndrome components while 3.70% had four and nobody met five criteria. Conclusion: Metabolic Syndrome is common amongst Toupouri men of Yaoundé.