The present study attempt to evaluate the preliminary phytochemical screening and antimicrobial studies in tuber extract of Corallocarpus epigaeus (Rottl. and Willd.) Hook. f. Qualitative phytochemical analysis of samples in different solvent extract confirms the presence of various phytochemicals like Carbohydrates, Saponins, Tannins, Flavonoid, Alkaloids, Glycosides, Proteins, Phytosterol, Steroids, Phenols and Terpenoids. The solvent Petroleum ether, Benzene, Acetone, Chloroform, Ethyl acetate and aqueous extract showed good results. Disk diffusion method was used to study the antibacterial activity against Salmonella tiphy, Escherichia coli, Streptococcus pyogenes, antifungal activity against Candida albicans, and antiprotozoal activity against Entamoeba histolytica. It has been observed that the samples in different solvent tuber extract showed antibacterial, antifungal, and antiprotozoal activities by the formation of inhibitory zone. It may be attributed due to the presence of phytochemicals and may be used as antimicrobial agents.