Plasma cells in health and disease

Plasma cells are the only cells that sustain antibody production and hence are an essential part of immune system. In the bone marrow plasma cells produce immunoglobulins which assure long-term humoral immune protection and in the mucosa-associated lymphoid tissues (MALT) plasma cells secrete IgA which protect the individual from pathogens invasion. This review illustrates plasma cell development and their role in both health and disease.