This study aimed to determine the antioxidant activity as well as the phytochemical constituent of Carica papaya leaves. Extraction was performed by successive maceration methods using soxhlet solvent. Antioxidant activity was evaluated by DPPH radical scavenging assay. Based on the phytochemical analysis, it showed that extract of Carica papaya contains alkaloids, phenolic, flavanoids, tannin and its derivative anthraquinone. The result showed that papaya extract plant samples displayed, these phytochemicals has the tendency to inhibit the infections microorganism the minimum inhibitory concentration. The inference depicts that the papaya leaf phytoextracts do not have the bacterial effect else the bacteria Staphylococcus aureus more resistant to the phytoconstituents. The phenolic content achieved also a satisfactory result which also aid in antioxidant benefit.