Andrographis paniculata mostly the leaves and roots were used for medicinal purposes. The whole plant is also used in holistic health and longevity, a philosophy and system of healing the whole body, mind and individual. The present investigation was find to carry out the qualitative phytochemicals such as alkaloids, saponins, flavonoids, tannins, phenols, steroids, terpenoids, glycosides, and lipids, quantitative phytochemicals such as alkaloids, saponins, flavonoids, tannins, phenols, steroids, terpenoids, and glycosides, and antimicrobes such as Aspergillusfumigatus, A.flavous, A.hemicola, A.hemicola, A. terreus, A.niger, Penniciliumcitrinum, Candida albicans, Microsporumepidermophyton were identified in Andrographispaniculata were analyzed. The above all parameters are positively favour for medicinally valuable substances for human and animal environmental activities and behaviours for the natural ecosystem.