Fever is known both as a symptom and a disease. Many were affected by this without knowing its cause. Younger population to older is get affected by fever. In Ayurvedic system Fever can be correlated with jvara. The Jvara has many types caused by different doshas say Vata, Pitta and Kapha. "Panchatiktha Kwatha Churna" (PTKC) which is mentioned in the Hospital pharmacopeia of Arignar Anna Hospital of Indian Medicine is one of the drug indicated especially for this disease. This drug is also useful in treating skin disorders too. The aim of this paper is to explore the literary evidences of its use for both in Fever and Skin disorders in Ayurvedic system. More than 100 scientific papers were reviewed to justify the activity of the ingredients present in the PTKC. PTKC is made up of five ingredients. Further study is to be done to explore its activity scientifically and thereby standardizing the medicine.