C-reactive Protein (CRP) is an acute-phase protein that belongs to the pentraxin family of calcium dependent legend-binding plasma proteins. The human CRP molecule has five identical subunits. These subunits are made up of 206 amino acids and are non glycosylated polypeptide. This review focuses on the various biological roles of CRP, their normal values, methods of measurement, advantages and factors. CRP is closely related to cardiovascular disease and other diseases. Cardiovascular disease can be treated by both phytochemical and non phytochemical sources.