Colour is a major factor for acceptability of any food item. Now – a – days every food item available in market is dumped with synthetic food dyes. These synthetic food dyes are very harmful for our and our children health. Food dyes may have immediate effect or they may be harmful in the long run on constant exposure. Tartrazine is a popular and commonly used yellow food dye. It is a permitted synthetic food dye in India. The present review is aimed to discuss the noxious role of Tartrazine as it is used in numerous food items available in the market. Tartrazine shows a number of adverse effects on human being. The present paper recommended the limited use of Tartrazine in food items to protect our health, especially our children.