Synthesis of novel propenones (2E)-1-(C)-3-(6-methoxynaphthalen-2-yl) prop-2-en-1-one (3) by the condensation reaction. The new target compounds were analyzed for their structures using FT-IR,1H-NMR, 13C-NMR and LC-Mass further these newly synthesized compounds were screened for their anti-TB and anti-malarial agents and the results of each such studies of these synthesized compounds revealed to possess excellent activity.