Non keratinocytes are a group of cells in the oral mucosa which exhibit unique structural features and perform various functions. The Melanocytes, Merkel Cells, Langerhans Cells and Inflammatory cells constitute the group of oral non keratinocytes. These cells are also called clear cells and do not take part in epithelial maturation. Proper synchronization of the keratinocytes and non keratinocytes is essential for maintaining the epithelial homeostatsis. The non keratinocytes of the oral mucosa have been discussed here with a view to explore their origin, structure and functional characterestics in a concise pattern.