Modulatory effects of hibiscus rosa-sinensis l. during 10% d-glucose feeding in rats

In the present study, the modulatory effect of Hibiscus rosa-sinensis flower petals treatment on the levels of plasma glucose, insulin, lipids and glycoproteins in 10% D-glucose feeding for 4 weeks were examined. The H. rosa-sinensis flower petals (1000mg/kg of body weight) was mixed with normal chow diet and administrated for 4 weeks as preventive and curative effects. The levels of plasma glucose, insulin, lipids and glycoproteins were increased significantly, whereas the levels of plasma HDL was decreased in 10% D-glucose fed rats. Administration of H. rosa-sinensis flower petals reversed these hyperglycemic and hyperlipidemic statuses in 10% D-glucose fed rats. These observed effects were found to positively correlate with the proanthocyanidins and -carotene content of the H. rosa-sinensis flower petals. The present study concludes that the H. rosa-sinensis flower petals possess a significant beneficial effect on glucose, insulin, lipid profiles and glycoprotein moiety in addition to its antidiabetic and antiatherosclerotic effects. Thus, the results of the present study indicate a positive role of H. rosa-sinensis as a therapeutic agent for diabetes and atherosclerosis in 10% D-glucose fed rats.