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Metformin in extended release for the treatment of type 2 diabetes mellitus: Retrospective study in South India

Author: 
Dr. Aparna, S.H., Dr. Shreni Sunil Navalgi, Pradeep, B. K
Subject Area: 
Health Sciences
Abstract: 

Diabetes mellitus is a chronic and progressive condition among the most common metabolic diseases in general medical practice. Intensive lifestyle intervention and metformin can prevent or delay progression to diabetes. Over the past decade, lifestyle interventions have been translated across various settings, but little is known about the translation of evidence surrounding metformin use. The purpose of this study is to evaluate the effect of metformin extended release formulation on the glycemic control gastrointestinal tolerability and patient satisfaction. Design: Retrospective analysis over a 1-year period. We examined data from August 2016 to July 2017 from ESIC hospital Peenya, Bangaluru using a retrospective analysis of metformin prescription among adults. Data were analyzed in 80 patients with type 2 diabetes not well controlled by diet (glycated hemoglobin [HbA1c] .7.0% and 8.5%). Patients were given metformin XR (Metadoze IPR® BIOCON) for a period of 4 months at the maximum tolerated dose. We evaluated, HbA1c, fasting, postprandial glucose and body weight. Moreover, at the baseline and after 4 months, we also validated the patients by SF 16 questionnaire to assess patients’ satisfaction toward treatments. After 4 months, metformin XR gave a greater improvement in glycemic control. A reduction in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol was observed with metformin XR. Conclusion: Metformin XR formulation seems to be more effective in improving glyco-metabolic control, lipid profile in patients with type 2 diabetes mellitus. Fewer gastrointestinal side effects and a greater sense of well being and satisfaction were seen with this medication.

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