Iodine catalyzed: one-pot synthesis of 1, 4-dihydropyrano (2, 3-c) pyrazole analogous and antimicrobial activity

A simple and an efficient protocol wasfollowed for the synthesis of dihydropyrano(2,3-c) pyrazole analogous by a one pot and multicomponent reaction of ethyl acetoacetate, hydrazine hydrate, malononitrile and various substituted aldehydes in the presence of a catalytic amount of I2 in ethanol solvent medium. The structures of all the newly synthesized derivatives have been interpreted on the basis of analytical and spectral dataviz IR, 1HNMR, 13CNMR and LCMS. The anti-microbial activity was screening exhibited that most of the obtained compounds were found to have significant anti-microbial activity activitiesThe advantages of this method serves as the various benefits such as major yield, low reaction time, mild reaction condition, operational simplicity, easy work-up method with environment friendly nature and purification of products by non-chromatographic methods has been enveloped.