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Inhibition of cox-2 enzyme by the various extracts of leucas aspera for Anti-inflammatory activity in albino rat

Author: 
Sudhakara Reddy, M., Udaykiran, V., Sivasankar, R., Muniya Naik, M. and Subahan, M.
Subject Area: 
Life Sciences
Abstract: 

The present investigation was aimed at evaluating the ethanol extract of leaves of Leucas aspera has been found to possess antibacterial activity and Anti-inflammatory Activity, Cyclooxygenase (COX), also called Prostaglandin H Synthase or (PGHS) is a bifunctional enzyme exhibiting both cyclooxygenase and peroxidase activities. COX-2 products are responsible for modulating dynamic processes such as inflammation. COX-2 is the true molecular target for developing anti-inflammatory and analgesic agents. Pathogen free, Wistar strain albino rats were used in the present study, In order to study the anti-inflammatory activity of four extracts of Leucas aspera viz., petroleum ether, chloroform, ethanol, water extracts .whereas the purified fraction F5 of ethanol extract were screened for their in vivo COX-2 enzyme inhibition assay, And the purified fraction (F5) of ethanol extract it is essential to carry out the COX enzyme inhibition assay. The fraction F5 of ethanol extract of L. aspera has shown significant COX-2 enzyme inhibition activity. The chemical molecule present in the fraction F5 is responsible for the inhibition of COX-2 enzyme present in the blood plasma of experimental rats. The present study reveals that ethanolic extract of leucas aspera spreng showed significant anti-inflammatory activity and COX- II enzyme inhibition studies.

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