Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive chronic disease, so the patients are disturbed burdened. A chronic care model is very needed in the form of educational efforts based on patient's empowerment. Objective: To identify the effect of empowerment-based education on improving the self-care of patients with chronic obstructive pulmonary disease (COPD). Methods: the study used quasi-experimental with one group pretest-postest design. Fourty eight respondents were selected using consecutive sampling. COPD self-care questionnaire research instrument (COPDSC-C) has been tested for validity by 3 experts and the reliability of Cronbach Alpha self-care was 0.90. The data analysis were used frequency distribution and Wilcox on Signed Rank Test. Results: The self-care before intervention with adequate value category was 14.60% and with inadequate value category was 85.40%. The self-care after intervention had an adequate value of 95.80% and an inadequate value of 4.20%. There was a value of difference and increase of the patients' self-care between before and after the intervention of empowerment-based education with p value ˂ 0.05. Conclusion: Empowerment-based education intervention has an effect on the increasing self-care of patients with COPD.