The study has been designed for the evaluation of powder extract of Salacia Oblanga for hypolipidemic activity, biochemical changes in normal and Aluminium toxicity induced White Albino Wistar Female Rats. Oral administration of Salacia extract and Aluminium chloride for two weeks significantly lowered the serum alkaline Phosphatase, Serum Aspartate aminotransferase, urea, bilirubin and cratinine at 14th day.