Aim: The aim of the present study was to evaluate the impact of smile designing on oral health - related quality of life. Objectives: Comparative evaluation of health-related quality of life (OHQoL) in patients before treatment and after treatment ie:- after 1 month of smile designing. Methods: In this case series study, the impact of treatment on OHQoL was measured using the standard questionnaire OHIP 14. This tool was applied to 15 patients who visited department of Prosthodontics SPDC wardha, before and after 1 month of treatment. Results: A total of 15 patients participated in the study. The average mean score recorded before treatment was 2.65 which was reduced to 1.13 after smile designing treatment. OHIP-14 scores were shown a statistical significant difference before and after treatment and had a greatest impact on quality of life after treatment. As can be seen, comparison of the frequencies of these responses suggested that after treatment, changes in OHRQoL for almost all questions. Conclusion: This study showed a positive effect on the OHRQoL and a strong impact on social, psychological emotional daily life of each patient.