During active phase of tuberculosis, antibodies especially IgM and IgG are developed against different mycobacterial antigens and these can be detected in patients’ sera. Patients with confirmed tuberculosis reporting to the Department of Thoracic Medicine and General Medicine of Govt Rajaji Hospital, Madurai were taken up for the present study. Of the 80 patients, 50 were (M=38, F=12) in PTB group and 30 (M=19, F=11) in EPTB group. Their age ranged from 19 to 45 years. Blood samples from 21, age and sex matched healthy control were included. IgG test was positive in 20 (8 PTB & 12 EPTB) of the 80. In the present study, IgG positive status was more among EPTB and it was significant (P<0.001).
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