Hp-β-cd based voriconazole niosome for ocular drug delivery: In vitro, antifungal & stability assessment

The main objective of drug delivery system to the eye is to improve existing ocular dosage forms and exploit newer drug delivery system for improving the therapeutic efficiency. The present study was to prepare & evaluate Voriconazole Niosome using non ionic surfactant like Span 60, Tween 80 & Brijj 30 in the presence of cholesterol & a negative charge inducer dicetyl phosphate (DCP) in different molar ratios & by employing a thin film hydration technique & were investigated morphology, entrapment efficacy, zeta potential, particle size, in-vitro release, physical stability, antifungal activity The entrapment efficiency (EE %) & in-vitro drug release of all formulation follows decreasing order: Span 60>Tween80> Brijj 30.The formulation VN-2 (1:1:1) molar ratio of Span 60, cholesterol & DCP gave the most advantageous entrapment (84.08±1.00 %) & release rate(Q 8h = 84.34±2.09%) as compared to other compositions. The study concluded that the Voriconazole loaded niosomes to be effective in sustaining the drug release leading to decreased side effects & increased patient compliance.