Gonadal hormone profile and semen quality assessment of the diabetic patients under regular and irregular treatment mode in the age group of 25-40 years: A duration dependent comparative approach

The present study was conducted to investigate the duration dependent changes in gonadal hormone and semen quality of the diabetic patients under regular and irregular treatment mode. In these aspect blood glycemic sensors, gonadal hormone profile, oxidative stress sensors in sperm pellet were assessed. Spermatological profiles were evaluated for testing the semen quality. Levels of blood glycemic sensors, gonadal hormones and values of spermatological parameters were corrected in diabetic patients under regular treatment mode for 4 to 5 years upto a certain and significant levels but were not changed further along with extension of the duration of the said treatment upto 15 years. But in case of irregular treatment the values of these parameters were changed towards the pathological direction further along with the extension of the duration of the treatment in respect to 4 to 5 years of treatment suffering from diabetic. Serum insulin and C-peptide were increased significantly in diabetic patient under regular treatment mode for 4 to 5 years in respect to control but these levels were stable when duration of the treatment was increased further. In case of diabetic patient under irregular treatment mode these levels were decreased along with extension of the duration of the treatment. Oxidative stress in sperm was increased in diabetic patient under irregular treatment mode in respect to diabetic patients under regular treatment mode in duration dependent manner. Though, oxidative stress in sperm showed a tendency to be lowered in diabetic patient who received regular treatment mode for 4 to 5 years in respect to irregular treatment, but all the levels of the sensors come stable when that duration of the treatment mode was extended beyond 4 to 5 years upto 15 years. So it may be concluded that regular treatment is more beneficial for recovery of testicular hypofunction in diabetic patients in respect to irregular treatment. Moreover, irregular treatment mode may exerts more deleterious effect on testicular physiology in diabetic patients along with extension of this treatment habit.