Vitamin D is vitamin and hormone with huge range of calcium dependent functions. Chronic kidney disease and diabetic nephropathy patients have a high incidence of cardiovascular and infectious morbidities. Increasing evidence indi vitamin D deficiency and cardiovascular and infectious mortality risks. Kidne is a target organ for Vitamin D3. This article is to review and summarize the pleiotropic effects of Vitamin D in patients with Diabetes Mellitus and Diabethic Nephropathy. -dependent and calcium-non- cates a relationship between