The present study reports the effect of leaf extracts of Hygrophila ringens (L.) on the blood sugar and body weight changes in alloxan induced albino mice and acute toxicity. The results showed that no mortality and abnormal behaviour was observed even after administration of a dosage of 2000 mg/Kg of body weight in the treated mice. A comparison of blood sugar levels & weight changes between treated & untreated mice indicated distinct changes after 21 days. The preliminary studies also suggest that the aqueous leaf extract of H. ringens (L.) contained safe principles and thus Hygrophila ringens (L.) could be a more useful plant possessing medicinal properties.