Evaluation of correlation between post prandial dyslipidemia and angiographic severity of coronary artery disease in type 2 di-abetes mellitus with special reference to triglyceride levels

Background: The dyslipidemia of diabetes in the postprandial phase is a major determinant of the atherogenicity. Postprandial high LDL and TG may account for up to fivefold increase in atherosclerosis in the diabetic patients. Objective: In this study we investigated the correlation of postprandial dyslipidemia with angiographic severity of CAD in type -2 diabetic patients. Methods: 50 type-2 diabetic patients (37 male, 13 female) were screened for glycemic control (HBA1C), WHR (waist hip ratio), BMI (body mass index), fasting and postprandial lipid Profile. CAD was evaluated in terms of vessels involved, site of lesion, percentage of coronary stenosis and morphology of the lesions. Result: The mean TG levels in diabetic with CAD and without CAD were 168.41±20.32 and 145±16.33, in fasting state (p <0.001) and 190.25±19.08 and 154.54±21.50 in postprandial state, respectively (p<0.0001). Postprandial hypertriglycerdemia is associated with more severe CAD in terms of number of vessels involved, and type, number and morphologic severity of lesions on angiography. Conclusion: We concluded that there is a definite correlation between severity of CAD and postprandial hypertriglyceridemia in diabetic patients.