Evaluation of anti-bacterial activity of high valued medicinal plant extracts against multi-drug resistant pseudomonas aeruginosa and proteus vulgaris

Human pathogenic bacteria have employed high levels of multidrug resistance (MDR) with enhanced morbidity and mortality. MDR develop hindrance in disease control by intensifying the possibility of spreading of resistant pathogens, thus, declining efficacy of treatment. MDR in bacterial infections has impaired the current antimicrobial therapy and demanding the search for other alternatives. Search for natural product extracting from high valued medicinal plants are the alternative source for discovery of new drugs useful against MDR bacteria. Henceforward, this study is designed to investigate the in vitro antibacterial activity of selected medicinal plants extracts against Pseudomonas aeruginosa and Proteus Vulgaris in comparison with commercial antibiotic discs using disc diffusion method. Different fractions of eight high valued medicinal plants were screened. The fractionated extract of Chenopodium album, Quercusincana, Zizipus jujube leaves, Zizipus jujube Flower, Grevillea robusta, Corydalis govaniana, Solanum nigrum showed antibacterial activity confirming through zone of inhibition ranging from 0-18.3 mm against Pseudomonas aeruginosa and Proteus Vulgaris. While Trifoliumrepens, Lamoniumcabuliciumfailed to control bacterial growth on disc diffusion. We suggest that the protocol used in this study is useful for the investigation of more plants used for antibacterial activity and plant having active natural products serve as a source for antibacterial compounds.