Herpes zoster, an agonizing blister forming disease caused by Varicella zoster virus 1,2,3and analgesics even opioids fails cease agony of pain , local; anesthetics only provide transient pain relief 4,5,6 and accidental observation of complete relief of neurological pain with a composite Epineuron (Epalrestat and methylcobalamine ), intended to evaluate the composite in management of Herpetic neuralgia. 124 patients of Herpes zoster involving various body part, without any associated other disease were evaluated comparatively for pain relief and safety margin. A composite Epineuron SR (Epalrestat 150mg and Methyl cobalamine 1500µg) daily with Famciclovir oral and Acyclovir as topical application in trial group, while placebo and Antiviral drug in control group. All patients taking trial drug had marked relief in agony of pain in mean duration of 24±4 hrs, blister healing in 9±2 days, complete pain relief in 14±4 days and all had excellent clinical recovery without any effect or alteration in hematological, hepatic and renal parameters with 100% compliance.
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