Effect of sinapic acid on membrane bound enzymes and lipid profile in normal and streptozotocin-induced diabetes in wistar rats

The aim of the study was to evaluate membrane bound enzymes and lipid lowering effects of sinapic acid in normal and streptozotocin induced diabetic rats. Diabetes was induced in female wistar rats by a single intraperitoneal administration of streptozotocin (45 mg/ kg BW). Rats were divided into six groups: normal (untreated), normal + sinapic acid (15 mg/kg), normal + sinapic acid (30 mg/kg), diabetic control, diabetic + sinapic acid (15 mg/kg) and diabetic + sinapic acid (30 mg/kg). Diabetic rats exhibited increased level of plasma glucose and decreased levels of liver and muscle glycogen and membrane bound enzymes such as Na+/K+-ATPase, Ca2+-ATPase and Mg2+-ATPase. STZ also caused significant elevation in total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol with consequent reduction in high density lipoprotein cholesterol in serum. Treatment with sinapic acid for a period of 35 days restored all these parameters to near normal. The results of the present study revealed that sinapic acid possesses a potential lipid lowering effect in streptozotocin -induced diabetic rats.