Aim: The study was aimed to assess the effect of psychoeducation on knowledge, attitude and burden of caregivers of clients with bipolar affective disorder. Methods and materials: One group pre-test, post-test design was adopted for the study. Forty caregivers of bipolar affective disorder (BPAD) who fulfilled the inclusion criteria were recruited for the study. A pre-test was conducted to assess their level of knowledge, attitude and burden. Following this, a structured teaching programme regarding BPAD was administered to the study subjects in two sessions of 45 minutes each. A post-test was conducted after seven days. Results: The study results revealed that majority of care givers possessed adequate knowledge and neutral attitude. The educational programme was found to be effective in improving the knowledge, attitude and reducing the burden (p<0.01) of caregivers of bipolar affective disorder.