A comprehensive study on synergistic effect of antihypertensive drugs with statin derivatives and supportive therapy in managing stroke patients: a prospective observational study

Background: Stroke remains a significant cause of morbidity and mortality around the world, necessitating comprehensive strategies for effective management. This prospective observational study aimed to investigate the synergistic effects of hypertensive agents and supportive therapy in the management of stroke patients. As Hypertension is the major significant modifiable risk factor for causing stroke, its control is paramount in preventing recurrent events of stroke. Methods: This prospective observational study included 213 stroke patients admitted to the tertiary care hospital in south India. The patients received hypertensive agents and concurrent supportive therapy followed over a specified period when admitted to the hospital. Also, data collected through clinical assessments, patient-reported outcomes, and medical records review over a predetermined follow-up during a period of admission were analyzed. Statistical methods, including multivariate regression analysis, Descriptive Statics analysis, and Hypothetical test Z-test assessed the synergistic effect of hypertensive agents and supportive therapy in stroke management outcomes. Result: The study found the combined antihypertensive agent with stain shows a synergistic effect when compared to without statins. The combined hypertensive agent and supportive therapy brought a significant improvement in functional recovery. These outcomes are accessed including the rate of stroke reoccurrence, functional recovery, overall mortality rate, and quality of life improved. Conclusions: Preliminary findings suggest that the combined use of hypertensive agents with statin derivatives shows a synergistic effect as compared to those without statin. Also, multiple hypertensive therapy shows a higher synergistic effect as compared to double and single hypertensive therapy. This study also concludes that Supportive therapy is significantly associated with improved blood pressure control, functional recovery, and reduced incidence of complications in stroke patients. These findings underscore the multidisciplinary approach in stroke rehabilitation and suggest further research is required to optimize treatment patterns and improve patient quality of life outcomes.